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Personalized head and neck cancer therapeutics have greatly improved survival rates for patients, but are often leading to understudied long-lasting symptoms which affect quality of life. Sequential rule mining (SRM) is a promising unsupervised machine learning method for predicting longitudinal patterns in temporal data which, however, can output many repetitive patterns that are difficult to interpret without the assistance of visual analytics. We present a data-driven, human-machine analysis visual system developed in collaboration with SRM model builders in cancer symptom research, which facilitates mechanistic knowledge discovery in large scale, multivariate cohort symptom data. Our system supports multivariate predictive modeling of post-treatment symptoms based on during-treatment symptoms. It supports this goal through an SRM, clustering, and aggregation back end, and a custom front end to help develop and tune the predictive models. The system also explains the resulting predictions in the context of therapeutic decisions typical in personalized care delivery. We evaluate the resulting models and system with an interdisciplinary group of modelers and head and neck oncology researchers. The results demonstrate that our system effectively supports clinical and symptom research. 

Biocuration is the process of analyzing biological or biomedical articles to organize biological data into data repositories using taxonomies and ontologies. Due to the expanding number of articles and the relatively small number of biocurators, automation is desired to improve the workflow of assessing articles worth curating. As figures convey essential information, automatically integrating images may improve curation. In this work, we instantiate and evaluate a first-in-kind, hybrid image+text document search system for biocuration. The system, MouseScholar, leverages an image modality taxonomy derived in collaboration with biocurators, in addition to figure segmentation, and classifiers components as a back-end and a streamlined front-end interface to search and present document results. We formally evaluated the system with ten biocurators on a mouse genome informatics biocuration dataset and collected feedback. The results demonstrate the benefits of blending text and image information when presenting scientific articles for biocuration.